Barbiturates: Frequently Asked Questions Answered

No. Xanax belongs to a class of medications called benzodiazepines. Benzodiazepines and barbiturates are somewhat similar and act like CNS depressants. They increase GABA production in the brain. It controls the stress response and reduces CNS activity to produce a calming effect. Therefore, both drug types have been traditionally used to treat insomnia and seizures and cause drowsiness.

Yes. Barbiturates are central nervous depressants that decrease nerve activity and promote muscle relaxation. They do this by increasing gamma-aminobutyric acid production in the brain. This acid halts the action of stimulating neurotransmitters and affects the brain’s motor centers. Thus, barbiturates reduce breathing, heart rate, and blood pressure.

The time barbiturates remain in the urine, hair, and blood depends on their type and individual factors like age and health. Usually, barbiturates remain in the urine for 2–4 days and in the blood for 1–2 days. Sometimes, they can be detected in urine for up to 6 weeks. They can appear for three months, especially in hair follicle tests.

Barbiturate overdose toxicity happens due to excessive dosage of barbiturates. Symptoms usually involve foggy and unclear thinking, inadequate coordination, reduced level of consciousness, and respiratory depression. A barbiturate overdose can lead to serious complications. These may include noncardiogenic pulmonary edema, which is fatal due to severe shortness of breath.

No, alcohol is not a barbiturate, though most barbiturates have a similar effect as that of alcohol. Both substances are central nervous system depressants. Both have a sedative effect and can cause significant harm with consumption. Since alcohol and barbiturates both activate GABA receptors in the brain, they enhance each other's effects when combined.

No, barbiturates are not stimulants. They do not elevate your mood, boost your attentiveness, or make you feel more awake and energetic. Instead, barbiturates are depressants that slow down brain functioning. Their general uses are to treat health issues like anxiety, insomnia, headaches, or seizures. They are even effective as anesthetics.

No, trazodone is not a barbiturate. It is an antidepressant that treats the chemical imbalance in the brain. It is used to treat anxiety, depression, or a combination of both. Trazodone can also ease symptoms like poor sleep, low mood, and poor concentration. Barbiturates, on the other hand, also improve sleep and promote relaxation but by working as CNS depressants.

No. Ativan or lorazepam is not a barbiturate, but a benzodiazepine. This drug class replaced barbiturates on a large scale for both medical and recreational use. However, both Ativan and barbiturates are CNS depressants. Ativan treats insomnia, anxiety, status epilepticus, or sleep difficulties due to stress or anxiety. It also has an anesthetic effect, like barbiturates.

Yes, doctors still prescribe barbiturates. Specifically, they are Prescription Only drugs under the Medicines Act (1968). However, the Misuse of Drugs Act also classifies them as Class B drugs. This makes them controlled substances. Take extreme precautions to follow the recommended dosage when a doctor prescribes them for treating anxiety, seizures, or other CNS disorders.

Barbiturates are a vast category of drugs. Hence, the dosage varies on the particular barbiturate and for what it has been recommended. For example, 30–50 mg of the sedative Amytal is prescribed intravenously every 8–12 hours. For short-term treatment of insomnia, 100 mg of secobarbital may be prescribed to be taken orally at bedtime. However, overdoses are common even if one uses barbiturates for over two weeks. Hence, a doctor’s consultation is strictly recommended before consuming them.

Talk to our medical experts at Yashoda Hospitals today for speedy and expert medical advice and services. Let our experts answer your queries regarding uses, side effects, and dosage, and precautions with taking barbiturates.