1. Does Dapagliflozin cause weight loss?
Unlike certain diabetic medications, Dapagliflozin does not cause weight gain. Many patients report losing weight instead. This occurs through a fluid loss mechanism during the first phase of therapy, followed by a more steady reduction through a net calorie deficit (usually 200–300 kcal/day).
2. How does Dapagliflozin work?
Dapagliflozin is an SGLT2 inhibitor that acts in the proximal nephron and is responsible for releasing filtered glucose into circulation. This operates by causing your kidneys to extract more sugar from your blood and excreting it through your urine. Inhibiting this cotransporter lowers glucose recovery, increases glucose excretion, and lowers hyperglycemia.
3. Which is better, empagliflozin or Dapagliflozin?
Both Empaglifozin and Dapagliflozin are given to people with TYPE2 DM, usually in combination with a healthier diet and exercise. The key difference between them is based on improving other cardiometabolic markers. Empagliflozin is considered more effective than Dapagliflozin in lowering HbA1c and also lowers the risk of mortality from heart failure and stroke.
4. Is Dapagliflozin better than metformin?
Metformin is still the safest, most effective type 2 diabetes medication. Both are mainly used as combination medication to enhance blood sugar management. Dapagliflozin acts in the kidneys to prevent blood sugar absorption, while Metformin lowers the absorption of sugar from the stomach and liver, thus improving the body's glucose utilisation.
5. Can Dapagliflozin cause kidney failure?
Renal dysfunction is one of the most prevalent complications of uncontrolled type 2 DM, especially when proteinuria and obesity are present. Dapagliflozin affects the kidneys by increasing the quantity of sugar eliminated via the urine. In type 2 diabetes patients, SGLT2 inhibitors minimise renal glucose reabsorption and enhance glycemic control.
6. Does Dapagliflozin increase creatinine?
Dapagliflozin causes a modest rise in serum creatinine levels in the blood generated by skeletal muscle. This response is triggered mainly by the patient's age, renal illness, history of asthma medications, high BP, and heart disease that affects the urine glucose excretion. If this level rises by >40%, it might be an indication of diabetic complications.
7. Is Dapagliflozin safe to use?
Dapagliflozin is generally safe to use. Make sure your doctor has approved its usage and is aware of other medicines you are taking. For those who already have diabetes, this medication may induce severe low blood sugar episodes.
8. Does Dapagliflozin improve ejection fraction?
According to the outcome of research published in the Journal of the American Heart Association, Dapagliflozin dramatically improves both systolic and diastolic heart failure symptoms as well as ejection fraction. Dapagliflozin inhibits glucose reuptake in the kidneys, lowers blood sugar levels, and alleviates diabetes symptoms.
9. How is Dapagliflozin excreted?
Dapagliflozin is a selective SGLT2 inhibitor that inhibits glucose resorption in the kidney's proximal tubule, increasing urine glucose excretion and lowering blood glucose levels. It makes it simpler for the body to pass through urine by reducing the quantity of sugar produced by the liver as well as sugar absorption in the gut.
10. Who should not take Dapagliflozin?
Dapagliflozin is not suitable for all diabetic patients. Tell your doctor before starting the medicine in the following instances:
- Low kidney functions.
- Liver disease.
- History of allergic reaction to DM meds before.
- Have > glucose and ketones levels in urine.
- Heart disease.
- Type I DM.
- Have recurrent UTIs.
- Pregnant or breastfeeding mothers.
- Galactose intolerance.
- Have low salt levels in their body.
- Are < 18 yrs or > 75 yrs.
- People on loop diuretics.
